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The psychedelic used by Intrinsic Pathways is a well-known anaesthetic agent, given intravenously at low doses. It primarily works by blocking NMDA receptors in the brain, which helps balance two essential neurotransmitters: glutamate and GABA.
Glutamate acts as the brain's "accelerator", playing a crucial role in motivation, learning and memory, while GABA serves as the "brake pedal", reducing nervous system excitability and promoting calmness.
The increase in glutamate during the infusion triggers the release of Brain Derived Neurotrophic Factor (BDNF), a protein often compared to "fertilizer for the brain". BDNF promotes the growth of new neural pathways (neurogenesis) and enhances connectivity between existing pathways (synaptogenesis).
Neuroscience suggests that conditions such as depression, anxiety, addiction, PTSD and OCD may be linked to reduced neural density, connectivity and communication, which can contribute to low mood, excessive worry and unhealthy habits. By supporting neurogenesis and synaptogenesis, new brain regions are activated and interconnected, allowing for profound shifts in self-perception and reality.
These shifts can help people process trauma, resolve inner conflict, release suppressed emotions and transform core beliefs and behaviours. This medicine is always used in a clinical, supervised setting rather than for casual or recreational use.
Ketamine-assisted therapy combines psychedelic medicine with structured therapy to enhance and sustain the benefits of the psychedelic experience. The medicine temporarily increases brain flexibility, while psychotherapy helps you work with that flexibility in a focused, intentional way.
A useful analogy is to think of the brain as a mound of clay:
Under the right conditions, psychedelic-assisted therapy has been compared to experiencing years of therapeutic progress in just a few hours — but it still requires ongoing support, integration and healthy habits to turn insight into lasting change.
Research and clinical experience suggest that psychedelic-assisted therapy may be helpful for certain people struggling with:
It is not a quick fix or a magic cure, and it is not suitable for everyone. Careful screening, medical assessment and psychological preparation are essential before anyone is accepted into a programme.
No. Intrinsic Pathways uses a controlled medical protocol, in a monitored setting, with prescribed doses and professional support before, during and after the infusion. The focus is on safety, therapeutic benefit and long-term wellbeing — not on chasing a "trip" or escape.
Recreational use outside of a supervised medical context can be risky and is not recommended. If someone is curious about psychedelic-assisted therapy, the safest route is to speak with qualified medical and mental health professionals and to go through proper screening.
Kindly contact us via email on:
admin@intrinsicpathways.co.za
or call us on:
064 650 8247
Email: admin@intrinsicpathways.co.za
Phone: 064 650 8247
